Kyzatrex is an immediate-release oral pill containing the active ingredient testosterone undecanoate. It’s absorbed through the lymphatic system, bypassing the liver, and is then broken down by enzymes into testosterone, which the body can use.
An oral pill taken twice daily with food

In a six-month study involving 127 men diagnosed with testosterone deficiency, several significant health improvements were observed:

• 96% of the participants achieved normal testosterone levels within three months.

• There was a twofold increase in mean free testosterone levels.

• Notable improvements were recorded on the Aging Males’ Symptoms (AMS) scale

Benefits:

• Convenient to take

• Flexible dosing

• Achieves stable testosterone levels (limits peaks & troughs)

Limitations:

• Can increase blood pressure

• Prior to treatment: Two blood tests and one blood pressure reading

• 1 month after treatment: One blood test and one blood pressure reading

• 3 months after treatment: One blood test and one blood pressure reading

• 6 months after treatment, and every 6 months thereafter: One blood test and one blood pressure reading

Testogel is a topical gel that delivers testosterone through the skin via transdermal absorption, allowing it to enter the bloodstream and increase overall levels. Applied daily, Testogel helps maintain stable testosterone levels throughout the day.

• Applied once a day in the morning, to the upper arms and shoulders

• Comes in a pump form, delivered monthly

In a placebo-controlled trial with 274 patients, 82% (139 out of 169) of the men with hypogonadism who were treated with an optimised dose of testosterone gel attained normal testosterone levels within six months.

Benefits:

• Convenient to apply

• Flexible dosing

• Achieves stable testosterone levels

Limitations:

• Risk of transfer through skin-to-skin contact, requiring extra care during and after application

• Can cause localised skin reactions

• Factors such as sweating and showering can affect absorption, and consequently the effectiveness of the dose taken

• Prior to treatment: Two blood tests and one blood pressure reading

• 1 month after treatment: One blood test and one blood pressure reading

• 3 months after treatment: One blood test and one blood pressure reading

• 6 months after treatment, and every 6 months thereafter: One blood test and one blood pressure reading

Testosterone cypionate is a short-acting injection that works by steadily releasing testosterone into the bloodstream, replacing the testosterone your body is unable to make.

• A small injection self-administered on alternate days into subcutaneous fat (usually found around the abdomen)

Injectable TRT is effective at restoring testosterone levels to normal, with most effects starting to take place within 6 months after initiating treatment. The alternate-day dosing of testosterone cypionate allows for better testosterone level stability.

Benefits:

• Flexible dosing

• Achieves stable testosterone levels

Limitations:

• You have to self-inject every other day

• Absorption varies from person to person

• Requires extra care when handling and storing equipment

• Prior to treatment: Two blood tests and one blood pressure reading

• 1 month after treatment: One blood test and one blood pressure reading

• 3 months after treatment: One blood test and one blood pressure reading

• 6 months after treatment, and every 6 months thereafter: One blood test and one blood pressure reading

Nebido is a long-acting TRT containing testosterone undecanoate as the active ingredient. It’s suspended in an oily solution and injected into a muscle, where it’s gradually released over time. This slow-release formula ensures that your testosterone levels remain stable without causing a buildup in your blood.

• Nebido is administered by a clinician every 10 to 14 weeks into the buttocks.

In a study of 133 patients with erectile dysfunction and low testosterone levels, 1,000 mg of TU was administered initially, then again at 6 and 18 weeks. Over a period of 6 months, the study observed several significant health improvements in patients:

• Total testosterone levels increased by 183%

• Free testosterone levels increased by 181%

• Cholesterol levels decreased

• Erectile function improved in 77% of the patients

• Significant improvements were noted on the Ageing Males’ Symptoms (AMS) scale

Safety tests showed increases in haemoglobin, hematocrit, and PSA, but all remained within normal ranges, with no serious side effects observed.

Benefits:

• Injections only once every 3 months

• Injected by a clinician

Limitations:

• Requires post-injection monitoring

• Intramuscular injections can be painful

• It can be harder to achieve stable testosterone levels with injections since you're committed to the dose for three months.

• Prior to treatment: Two blood tests and one blood pressure reading

• 3 months after treatment: One blood test and one blood pressure reading

• 6 months after treatment: One blood test and one blood pressure reading

• 9 months after treatment: One blood test and one blood pressure reading

• 12 months after treatment, and every 6 months thereafter: One blood test and one blood pressure reading

Numan's high-strength testosterone supplement is a daily powdered blend of vitamins and minerals. Taken once daily, it supports balanced testosterone levels, boosts energy, aids muscle growth, and improves mood.

Key ingredients include zinc for testosterone, vitamin D3 for muscle function, and magnesium to reduce fatigue. It offers 12 times more fenugreek extract, 50% more zinc, and three times the vitamin D than standard supplements.

Supplements are not clinically proven treatments. Instead, they’re products taken to indirectly support testosterone production and maintenance, while bridging certain nutritional gaps.

D-aspartic acid: A natural amino acid that may increase hormones stimulating testosterone release.

Zinc: Essential for health, and a deficiency is linked to low testosterone; zinc supplementation can promote testosterone production in the testes and potentially increase levels long-term.

Magnesium: This mineral can boost free and total testosterone levels, with greater benefit observed in those who exercise.

Vitamin D: This vitamin supports normal muscle function and strengthens bones.

Fenugreek: A 12-week study showed that a daily 500-mg fenugreek supplement can significantly boost testosterone levels, with 90% of participants experiencing up to a 46% increase.

Benefits:

• Supports energy, muscle function, mood and testosterone levels

• Natural ingredients

Limitations:

• Not a proven clinical treatment for low testosterone

The high-strength testosterone supplement does not require routine monitoring, but we recommend scheduling blood tests every 6 months to keep track of your testosterone levels and wider blood count.

Tadalafil Daily provides a steady, low dose of tadalafil, helping to produce an erection whenever you need one after 3-5 days of consistent use.

While it doesn't address the underlying cause of erectile dysfunction or increase sexual desire, it allows for spontaneous sex as it remains active in your system. It works by increasing blood flow to the penis, which results in longer, firmer erections.

Tadalafil Daily is a medication that is very effective at alleviating erectile dysfunction, a common symptom of low testosterone. It does not, however, impact testosterone levels.

Benefits:

• Daily dosing to remove the “planning phase” out of romance

• Convenient to take

Limitations:

• Does not affect testosterone levels

Tadalafil Daily does not require routine monitoring, but we recommend scheduling blood tests every 6 months to keep track of your testosterone levels and wider blood count.