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Here’s the breakdown of what happens in your body to get the blood flowing again:1
Stimulation increases blood flow
Arousal triggers cGMP, a molecule that boosts blood flow to the penis and helps you get an erection.
Limited blood flow stops an erection
In people with ED, an enzyme called PDE5 breaks down cGMP too quickly, reducing blood flow and causing the erection to fade.
Medication promotes a firmer erection
ED treatments block PDE5, helping more blood reach the penis. This leads to firmer, longer-lasting erections.
Identify what’s going on and tackle both the symptom and the cause:2-5

Low testosterone

Heart disease

Diabetes
Reclaim your confidence in the bedroom with clinically proven ED treatments delivered to your door.

Take a simple blood test to uncover what’s really going on.

Speak with our men’s health experts to make a plan that tackles the root cause, not just the symptoms.

Dr David Weinstein
Men's Health Medical Lead
MBBS MRCGP PGCERT Med Ed.

Mo Dekmak
Head of Clinical Product
MPharm PgDip IPresc

Dr Dimitris Schizas
Numan Doctor
MBBS MRCGP MSC BSSM

Dr Michael Lacey
Numan Doctor
MBChB BSc (Hons) MRCGP

Dr Alexandra Davidson
Numan Doctor
BSc (Hons) MBBS MRCGP AFHEA MA (Hons) AFMCP

Abby Watts
Senior Nurse Prescriber
BSc Adult Nursing, IP




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1. Dhaliwal A, Gupta M. PDE5 inhibitors. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2025.
2. Rabijewski M, Papierska L, Kozakowski J, Zgliczyński W. The high prevalence of testosterone deficiency in population of Polish men over 65 years with erectile dysfunctions. Aging Male [Internet]. 2012;15(4):258–62.
3. Olinic DM, Stanek A. Vascular diseases: Etiologic, diagnostic, prognostic, and therapeutic research. Life (Basel, Switzerland). 2023;13(5).
4. Defeudis G, Mazzilli R, Tenuta M, Rossini G, Zamponi V, Olana S, et al. Erectile dysfunction and diabetes: A melting pot of circumstances and treatments. Diabetes/metabolism research and reviews. 2022;38(2): e3494.
5. Watts M. Diabetes and obesity. Diabetes. https://www.diabetes.co.uk/diabetes-and-obesity.html
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