Alli is suitable for adults with a Body Mass Index (BMI) of 28 or higher. It's not recommended for those with certain medical conditions, such as chronic malabsorption syndrome or cholestasis, and it's not suitable for pregnant or breastfeeding women.

MEDICATED WEIGHT LOSS

Alli

Q: What is Alli and how does it work?

Alli is a weight loss medication containing orlistat. It works by preventing the absorption of about a third of the fat you eat. By blocking the enzyme lipase, which is needed to break down dietary fat, Alli reduces the amount of fat your body absorbs, leading to weight loss.

Q: How should I take Alli?

Take one capsule with water immediately before, during, or up to one hour after each main meal. If you skip a meal or eat a meal without fat, you can skip your Alli dose. The maximum recommended dosage is three capsules per day.

Q: What are the common side effects of Alli?

Common side effects include gastrointestinal issues like oily spotting, gas with discharge, urgent bowel movements, fatty or oily stools, and stomach pain. These effects are due to undigested fats passing through your digestive system.

Q: Do I need to follow a special diet while taking Alli?

For the best results, combine Alli with a balanced, reduced-calorie diet that contains about 30% of calories from fat. Distribute your intake of fat, carbohydrates, and protein evenly across your three main meals.

Q: Is Alli safe for long-term use?

Alli is intended for short-term use, usually a few months. Long-term safety and efficacy depend on individual health conditions and should be assessed by a healthcare provider.

Q: How does a health coach support me?

Health coaches are here to amplify the benefits of your weight loss journey with Alli by helping you integrate sustainable habits in <a href="https://www.numan.com/weight-loss/diet" target="_self" linktype="url">nutrition</a>, <a href="/weight-loss/exercise/" uuid="c98891aa-d114-401b-bfbb-4328a1dc38ba" target="_self" linktype="story">exercise</a>, <a href="/weight-loss/sleep/" uuid="2a3f9279-c01e-4acb-b2e5-6f0fb74520ab" target="_self" linktype="story">sleep</a>, and <a href="/weight-loss/tips/" uuid="e30b9545-eae3-4341-bf6e-5ba4a21d8feb" target="_self" linktype="story">mindset</a>. While Alli suppresses appetite, your coach provides tailored strategies to help you sustain this progress, such as setting achievable goals, keeping you motivated, and offering a balanced approach to nutrition and fitness.

Q: How does Numan’s approach to nutrition support my weight loss goals?

Our nutrition philosophy complements Alli’s effects by focusing on balanced, sustainable changes that fit your lifestyle. Alli helps limit your cravings, while our health coaches provide practical guidance on nutrient-rich foods that fuel your body. Together, these approaches aim to create a dietary shift that promotes long-term success and reduces dependence on fad diets.<a href="/weight-loss/diet/" uuid="4b8a924f-e54f-4dcb-9910-7fa29dd9302f" target="_self" linktype="story">Learn more about our approach to nutrition</a> and how it pairs with Alli to support effective, lasting weight loss.

How it works: Lipase inhibitor blocks fat absorption

Effect: An average of 8.6% body weight in 12 months*

From£229.00£135.00 / month

*Based on weight loss in orlistat-treated patients after 1 year. Rössner, S., Sjöström, L., Noack, R., Meinders, A.E., Noseda, G. and (2000), Weight Loss, Weight Maintenance, and Improved Cardiovascular Risk Factors after 2 Years Treatment with Orlistat for Obesity. Obesity Research, 8: 49-61.”

How Alli works for weight loss

Alli works by blocking certain enzymes in your gut, reducing fat absorption by about 25%*. This leads to weight loss as less dietary fat is absorbed by your body. It's most effective when combined with a balanced diet rich in fruits and vegetables, where about 30% of calories come from fat.

_{* Alli Homepage for HealthCare Professionals, GlaxoSmithKline.}_{http://www.allihcp.com}_{. Accessed Jan 2024}

What are the side effects of Alli?

Common gastrointestinal side effects include:

Oily spotting on underclothes
Gas with discharge
Urgent or increased bowel movements
Fatty, oily stools
Stomach pain
Faecal incontinence

Other possible effects:

Headaches, fatigue, anxiety
Respiratory or urinary infections
Menstrual irregularities, dental problems
Low blood sugar (in type 2 diabetes)

Meet the experts

Numan’s Weight Loss Programme is crafted by a team of specialists who understand the multifaceted challenges of weight management. Leveraging the latest insights in metabolic science, appetite regulation, and psychology, our experts create tailored treatments and strategies designed for lasting success.

Our approach includes the use of Alli, a lipase inhibitor that reduces the absorption of dietary fats, making it easier to achieve your goals. Alongside support from healthcare professionals and lifestyle coaches, the programme is personalised to adapt to your unique needs at every stage.

Learn more about our experts

Dr Luke Pratsides
Head of Medical
MBBS MSc MRCGP MFCI
Sophie Kanani
Health Coaching Operations Manager
BSc (Hons) Dip
Jess Uffindell
Registered Nutritionist
BANT CNHC BSc (Hons)
Mo Dekmak
Clinician
MPHARM PGDIP IPRESC
Shivani Sharma-Savani
Prescribing Lead
MPharm PGCert PCert IP
Faye Townsend
Senior Health Coach
AfN BSc BDA PGDIP BPS
Dr Nimlan Shanmugathas
Clinical Product Manager
MBBS BSc (Hons) MRCS PGDip

Learn more about our experts

OTHER SOLUTIONS

Understanding your options: weight loss treatments

Medicated weight loss solutions vary in their mechanisms and effectiveness. While Alli reduces fat absorption, other treatments, such as GLP-1 receptor agonists like Wegovy, suppress appetite to help you feel full longer and manage cravings. Choosing the right treatment depends on your individual needs and health goals.

Learn more about other treatments

Weight Loss Programme + Mounjaro

Clinically-proven weight loss

From£229.00£135.00 / month

Learn more

Weight Loss Programme + Wegovy

Clinically-proven weight loss

From£229.00£135.00 / month

Learn more

Glucomannan for Weight Loss

Helps keep you full

From£12.66 / bottle

Buy now

Learn more

Weight Loss Blood Test

Discover the impact of weight loss on your body and health

From£78.00 / kit

Blood test kit with purple and yellow vial

Buy now

Learn more

Weight Loss Programme + Mounjaro

Clinically-proven weight loss

From£229.00£135.00 / month

Learn more

Weight Loss Programme + Wegovy

Clinically-proven weight loss

From£229.00£135.00 / month

Learn more

Glucomannan for Weight Loss

Helps keep you full

From£12.66 / bottle

Buy now

Learn more

Weight Loss Blood Test

Discover the impact of weight loss on your body and health

From£78.00 / kit

Buy now

Learn more

Learn more about other treatments

Free, discreet delivery
No names, no logos, no delivery fee.
Ongoing clinical support
Access expert clinicians and medical advice.
Pause or cancel any time
You're always in control of your treatment.
Innovative treatments
Advanced, clinically-proven medications.
Rated excellent on Trustpilot
4.5* from over 15,000 people like you.
Trusted
Regulated by the Care Quality Commission.
UK licensed
Medications and clinicians.
Free, discreet delivery
No names, no logos, no delivery fee.
Ongoing clinical support
Access expert clinicians and medical advice.
Pause or cancel any time
You're always in control of your treatment.
Innovative treatments
Advanced, clinically-proven medications.
Rated excellent on Trustpilot
4.5* from over 15,000 people like you.
Trusted
Regulated by the Care Quality Commission.
UK licensed
Medications and clinicians.

Health coaching designed for you

Health coaching forms the core of our programme, aiming to foster lasting lifestyle changes. Paired with Alli’s fat-blocking support, our coaches guide you in building practical, sustainable habits across nutrition, exercise, sleep, and mindset.

While Alli helps to reduce fat absorption, our coaches enhance these benefits with advice on balanced meals, enjoyable physical activity, and effective routines for better health. Together, they provide the support needed to make meaningful progress and achieve your goals.

Learn more about coaching

Learn more about coaching

Tackling obesity: a new approach

Obesity is a complex condition influenced by a range of biological, psychological, and environmental factors. At Numan, we recognise the importance of addressing these challenges with science-backed solutions like Alli, which actively reduces fat absorption. This medication acts as a stepping stone towards building healthier habits and achieving sustainable weight loss.

With obesity impacting millions across the UK, Numan offers a holistic programme that combines medical expertise with personalised guidance. By focusing on the root causes of weight gain, we help you take control of your health, with support tailored to your unique needs and goals.

REAL PEOPLE, REAL IMPACT

Over 500,000 people have trusted us to improve their health

See more testimonials

I feel I can live a longer, happier life with less risk of cardiovascular issues. I've struggled with being overweight for many years, so the impact has been life-changing.

Rebecca, 33

I discovered an old bag of clothes and couldn’t believe how many of them fit me where I would have had no chance before. I feel amazing. I think I look much better than I ever did.

Andy, 55