TABLETS AND INJECTIONS

Mounjaro targets both the GLP-1 and GIP receptors, meaning that as well as slowing stomach emptying and increasing fullness and satiety, it plays an additional role in enhancing the body's ability to use stored fat as energy, and potentially providing broader weight management effects.⁶

• Mounjaro is taken as a once-weekly, dose-set pen injection.

A trial with 2539 adults found that weekly tirzepatide (5 mg, 10 mg, or 15 mg) over 72 weeks achieved significant weight loss in overweight and obese patients, with a higher percentage achieving 5%, 10%, 15%, and 20% or more weight loss compared to placebo.¹

Always read the label and store as instructed.

• Nausea

• Diarrhoea

• Vomiting

• Pancreatitis (rarely)

*If you're prescribed this medication please read the patient information leaflet provided with the product for a full list of side effects.⁶ If you're concerned about any of this medication’s side effects, please contact one of our Numan clinicians or your local GP. For help on managing GLP-1 side effects, read our tips

Wegovy, brand name for semaglutide, works by targeting the GLP-1 receptor, slowing stomach emptying, increasing fullness, and reducing cravings. Semaglutide has been shown to reduce certain cardiovascular events by up to 20%.⁷

• Semaglutide is taken as a once-weekly, dose-set pen injection.

In a 72-week trial of 1,407 adults with obesity, once-weekly semaglutide 7.2 mg gave a mean weight reduction of 21%, against 2% on placebo, with around nine in ten reaching at least 5% weight loss. Figures assume full adherence alongside lifestyle support.²

Always read the label and store as instructed.

• Nausea

• Diarrhoea

• Vomiting

• Pancreatitis (rarely)

*If you're prescribed this medication please read the patient information leaflet provided with the product for a full list of side effects.⁷ If you're concerned about any of this medication’s side effects, please contact one of our Numan clinicians or your local GP. For help on managing GLP-1 side effects, read our tips

The Wegovy Pill contains semaglutide, the same active ingredient as the Wegovy injection, in a once-daily tablet. It was the first oral GLP-1 medicine approved by the MHRA for weight loss in the UK, in June 2026.⁹ It works the same way, mimicking the gut hormone GLP-1 to slow digestion, increase fullness, and reduce appetite.

• Taken as one tablet daily, first thing in the morning.

In OASIS 4, a trial of 307 adults, oral semaglutide 25mg alongside lifestyle support led to an average weight loss of 16.6% of body weight at 64 weeks, compared with 2.2% on placebo.³

The tablet only absorbs properly on an empty stomach. Take it with no more than 120 ml of still water, then wait at least 30 minutes before eating, drinking, or taking any other medication.⁸ Always read the label and store as instructed.

• Nausea

• Constipation

• Vomiting

• Pancreatitis (rarely)

*If you're prescribed this medication please read the patient information leaflet provided with the product for a full list of side effects.⁹ If you're concerned about any of this medication’s side effects, please contact one of our Numan clinicians or your local GP. For help on managing GLP-1 side effects, read our tips

Foundayo contains orforglipron, a non-peptide small molecule that targets the GLP-1 receptor to reduce appetite and increase fullness. The MHRA authorised it in August 2026, making the UK the first country in Europe to do so.¹⁰ Because of its chemistry, it can be taken at any time of day, with or without food, and with no restriction on water.¹¹

• Taken as one tablet daily, with or without food.

In ATTAIN-1, a phase 3 trial of 3,127 adults, people on the highest dose (17.2mg) lost an average of 12.4% of their body weight at 72 weeks, compared with less than 1% on placebo.⁴

Doses increase gradually from 0.8mg to a maximum of 17.2mg, with at least a month between each increase. You might find a lower dose works for you and stay on that dose. We’ll go at whatever pace works for you. Always read the label and store as instructed.

• Nausea

• Constipation

• Diarrhoea

• Vomiting

*If you're prescribed this medication please read the patient information leaflet provided with the product for a full list of side effects.¹⁰ If you're concerned about any of this medication’s side effects, please contact one of our Numan clinicians or your local GP. For help on managing GLP-1 side effects, read our tips.

Alli contains orlistat, which reduces the amount of dietary fat your body absorbs by blocking lipase, the enzyme responsible for breaking fats down. Around a quarter of the fat you eat passes through the body instead.⁵ It's the only treatment here available without a prescription, and the only one that isn't a GLP-1 medicine.

• Taken as an oral capsule, three times a day with fat-containing meals.

In a two-year randomised trial, adults taking orlistat 60 mg three times daily alongside a reduced-calorie, lower-fat diet had lost 6.8% of their body weight at two years, compared with 4.5% on placebo. They also regained less weight during the second year.⁵

• It’s recommended that you keep your fat intake to no more than 30% of your total calories, or about 15 grams of fat per meal

• Side effects can be unpleasant

• Frequent bowel movements

• Faecal incontinence

• Abdominal pain

• Diarrhoea

  *If you're prescribed this medication please read the patient information leaflet provided with the product for a full list of side effects.¹¹ If you're concerned about any of this medication’s side effects, please contact one of our Numan clinicians or your local GP.