What is promethazine?

Promethazine is an antihistamine medication with a sedating effect, making it helpful for promoting sleep.

How does promethazine work?

Antihistamines block histamines from attaching to receptors in the body. This prevents them from causing allergy symptoms, such as a runny nose, itchy eyes, and sneezing. However, antihistamines can also block histamines from attaching to receptors in the brain. As the chemical is involved in regulating sleep and wakefulness, this action causes drowsiness and aids restful sleep.

What are the side effects of promethazine?

Promethazine can cause a number of side effects, including drowsiness, dizziness, dry mouth, blurred vision, and constipation. In rare cases, it can also cause more serious side effects, such as seizures, heart problems, and liver damage.

Can promethazine be addictive?

Promethazine should be used cautiously. It’s typically prescribed for short-term use and in limited supply. It should be taken as needed, rather than daily, to help reduce any risk of psychological dependence on promethazine.

In what strengths is promethazine available?

Promethazine is available in tablet form with strengths of 10mg, 20mg, and 25mg. The dose depends on the condition it is being used to treat. For short-term insomnia, a dose of 25mg to 50mg at night is typically recommended.

How do I take promethazine for sleep?

Promethazine should only be taken as prescribed. The recommended adult dose for promethazine to aid sleep is 25 to 50 milligrams taken orally at bedtime. Follow these guidelines: Take the medication exactly as prescribed. Do not exceed the recommended dosage. Take promethazine shortly before bedtime to maximise its effects. Swallow tablets whole with water. Avoid alcohol and any other drugs with sedative properties while using promethazine. Use promethazine for sleep when necessary and prescribed. Short-term use is recommended.

Promethazine: fall asleep and stay asleep

Sleep Better, Feel better

Promethazine is a trusted antihistamine medication which promotes restfulness. With its sedating properties, promethazine helps you drift off for deep, uninterrupted sleep.

The science

Promethazine: how it works

ONE

Targets your brain chemicals

Promethazine blocks a chemical in your brain called histamine, which plays an important role in the sleep-wake cycle.

TWO

Deepens your sleep

Histamine promotes feelings of wakefulness. Blocking the action of this chemical makes it easier to fall into an uninterrupted sleep.

THREE

Resets your body clock

Taking promethazine as prescribed helps your body to adjust and correct the sleep-wake cycle so that you reset your natural circadian rhythm. This promotes healthy restorative sleep.

Evidence-based sleep solutions

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Melatonin and promethazine are treatments proven to promote deeper and longer sleep.

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Trusted

Regulated by the Care Quality Commission.

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Medications and clinicians.

Free, discreet delivery

No names, no logos, no delivery fee.

Ongoing clinical support

Access expert clinicians and medical advice.

Pause or cancel any time

You're always in control of your treatment.

Innovative treatments

Advanced, clinically-proven medications.

Rated excellent on Trustpilot

4.4* from over 15,000 people like you.

Trusted

Regulated by the Care Quality Commission.

UK licensed

Medications and clinicians.

Free, discreet delivery

No names, no logos, no delivery fee.

Ongoing clinical support

Access expert clinicians and medical advice.

Pause or cancel any time

You're always in control of your treatment.

Innovative treatments

Advanced, clinically-proven medications.

Rated excellent on Trustpilot

4.4* from over 15,000 people like you.

Trusted

Regulated by the Care Quality Commission.

UK licensed

Medications and clinicians.

FAQS

Your questions answered

Knowledge

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Promethazine

Sleep Better, Feel better

The science

Promethazine: how it works

ONE

Targets your brain chemicals

TWO

Deepens your sleep

THREE

Resets your body clock

OTHER SLEEP SOLUTIONS

Effective treatments for better sleep

Evidence-based sleep solutions

FAQS

Your questions answered

Knowledge

Sleep: what you need to know

Start your treatment journey