Medication

Sleep Better, Feel better
Promethazine is a trusted antihistamine medication which promotes restfulness. With its sedating properties, promethazine helps you drift off for deep, uninterrupted sleep.
The science
Promethazine: how it works
ONE
Targets your brain chemicals
Promethazine blocks a chemical in your brain called histamine, which plays an important role in the sleep-wake cycle.
TWO
Deepens your sleep
Histamine promotes feelings of wakefulness. Blocking the action of this chemical makes it easier to fall into an uninterrupted sleep.
THREE
Resets your body clock
Taking promethazine as prescribed helps your body to adjust and correct the sleep-wake cycle so that you reset your natural circadian rhythm. This promotes healthy restorative sleep.
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FAQS
Your questions answered
Promethazine is an antihistamine medication with a sedating effect, making it helpful for promoting sleep.
Antihistamines block histamines from attaching to receptors in the body. This prevents them from causing allergy symptoms, such as a runny nose, itchy eyes, and sneezing. However, antihistamines can also block histamines from attaching to receptors in the brain. As the chemical is involved in regulating sleep and wakefulness, this action causes drowsiness and aids restful sleep.
Promethazine can cause a number of side effects, including drowsiness, dizziness, dry mouth, blurred vision, and constipation. In rare cases, it can also cause more serious side effects, such as seizures, heart problems, and liver damage.
Promethazine should be used cautiously. It’s typically prescribed for short-term use and in limited supply. It should be taken as needed, rather than daily, to help reduce any risk of psychological dependence on promethazine.
Promethazine is available in tablet form with strengths of 10mg, 20mg, and 25mg. The dose depends on the condition it is being used to treat. For short-term insomnia, a dose of 25mg to 50mg at night is typically recommended.
Promethazine should only be taken as prescribed. The recommended adult dose for promethazine to aid sleep is 25 to 50 milligrams taken orally at bedtime.
Follow these guidelines:
Take the medication exactly as prescribed.
Do not exceed the recommended dosage.
Take promethazine shortly before bedtime to maximise its effects.
Swallow tablets whole with water.
Avoid alcohol and any other drugs with sedative properties while using promethazine.
Use promethazine for sleep when necessary and prescribed. Short-term use is recommended.
Knowledge
Sleep: what you need to know
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